Recombinant Mouse CD86 [ICH3072]
$504.00
Recombinant Mouse CD86 [ICH3072]
Product Benefits:
ichorbio’s Recombinant Mouse CD86 is manufactured in a cGMP compliant facility. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information.
Expression Host:
Sf 21 Insect Cells
Formulation:
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Background:
CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.
Other Names:
BB7-2, B70, Ly-58, CD-86
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Biological activity:
The biological activity of Mouse B7-2 was determined by its ability to induce IL-2 secretion by human acute leukemia T cells. The expected ED50=0.05 -0.15 ug/ml in the presence of PHA.
Endotoxin level:
<1.0 EU/ug as determined by the LAL method. Suitable for in vivo use.
Amino acid sequence:
vetqa yfngtaylpc pftkaqnisl selvvfwqdq qklvlyehyl gtekldsvna kylgrtsfdr nnwtlrlhnv qikdmgsydc fiqkkpptgs iilqqtltel svianfsepe iklaqnvtgn sginltctsk qghpkpkkmy flitnstney gdnmqisqdn vtelfsisns lslsfpdgvw hmtvvcvlet esmkisskpl nftqefpspq tywkegdieg rmdpkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgk .
State of Matter:
Lyophilized.
Storage & Stability:
The predicted molecular weight of Recombinant Mouse B7-2 is Mr 51.8 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 60-65 kDa.
Predicted Molecular Mass:
The predicted molecular weight of Recombinant Mouse B7-1 is Mr 51.3 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 80-90 kDa.
N-terminal Sequence Analysis:
Val26
Use:
Products are for research use only. Not for use in diagnostic or therapeutic procedures
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