ichorbio’s Recombinant Human CD86 is manufactured in a cGMP compliant facility. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.
B7-2, CD86, B70, LAB72, CD28LG2, MGC34413
>95% by SDS-PAGE and analyzed by silver stain.
<1.0 EU/ug as determined by the LAL method. Suitable for in vivo use.
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Predicted Molecular Mass:
The predicted molecular weight of Recombinant Human B7-2 is Mr 52.7 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 85-95 kDa.
N-terminal Sequence Analysis:
Products are for research use only. Not for use in diagnostic or therapeutic procedures