Anti-Mouse IL-2 In Vivo Antibody – Low Endotoxin (JES6-1A12) [ICH1119]
$184.00 – $313.00
Bulk anti-IL-2 In Vivo Antibody – Low Endotoxin (JES6-1A12)
Product Benefits:
ichorbio’s anti-IL-2 In Vivo Antibody – Low Endotoxin (JES6-1A12) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio’s low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio’s low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin (<0.75EU/mg) at an even higher purity (98% versus 95%). ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
Target:
IL-2
Clone:
JES6-1A12
Isotype:
Rat IgG2a
Other Names:
Interleukin-2, Il2, T-cell growth factor, TCGF
Uniprot:
Host:
Rat
Species Reactivity:
Mouse
Specificity:
Anti-IL-2 In Vivo Antibody – Low Endotoxin (JES6-1A12) recognizes an epitope on Mouse IL-2
Purification Method:
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background:
Interleukin-2 (IL-2) is a potent T-cell mitogenic cytokine that functions as a primary regulator of T cell homeostasis and has been considered a prime candidate immunotherapeutics, both for increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 plays a key role in setting the balance between immunity and tolerance. This cytokine has a dual role as the regulator of the two main phases of the immune response (proliferative and suppressive). IL-2 also stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. The JES6-1A12 antibody has been shown to neutralize IL-2 in vivo.
Immunogen:
Purified Recombinant Mouse IL-2 (>98%)
Concentration:
1.0 mg/ml
Formulation:
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
Purity:
>95% by SDS-PAGE and HPLC
>98% by SDS-PAGE and HPLC
Endotoxin:
≤ 1.0 EU/mg as determined by the LAL method
≤ 0.75 EU/mg as determined by the LAL method
Aggregation:
Aggregation level ≤ 5%
Aggregation level ≤ 1%
Storage:
anti-IL-2 In Vivo Antibody – Low Endotoxin (JES6-1A12) is stable when stored at 2-8°C. Do not freeze.
Applications:
ELISA, ELISPOT, Immunoprecipitation, Neutralization, Western Blot
Application Notes:
Each investigator should determine their own optimal working dilution for specific applications.
Use:
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control:
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