Anti-Mouse IL-1R In Vivo Antibody – Low Endotoxin (JAMA-147) [ICH1117]
$320.00 – $2,140.00
Bulk anti-IL-1R In Vivo Antibody – Low Endotoxin (JAMA-147)
Bio X Cell:
ICH1117 is up to 11% cheaper for academia & non-profits and up to 51% cheaper for industry than the equivalent product BE0256 from Bio X Cell.
We guarantee that our antibody will perform exactly the same in your experiments as BE0256 from Bio X Cell: if it doesn’t we will refund your purchase and pay for the Bio X Cell antibody to be delivered to you as soon as possible.
Product Benefits:
ichorbio’s anti-IL-1R In Vivo Antibody – Low Endotoxin (JAMA-147) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio’s low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio’s low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin (<0.75EU/mg) at an even higher purity (98% versus 95%). ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
Target:
IL1R1
Clone:
JAMA-147
Size:
ichorbio’s JAMA-147 in vivo antibody is available in the following bulk sizes:
1mg, 5mg, 25mg, 50mg and 100mg
ichorbio regularly manufactures multi-gram amounts of our anti-IL-1R JAMA-147 clone – please contact us for pricing.
1mg, 5mg, 25mg, 50mg and 100mg
ichorbio regularly manufactures multi-gram amounts of our anti-IL-1R JAMA-147 clone – please contact us for pricing.
Isotype:
Armenian Hamster IgG
Other Names:
Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha,
IL-1R-alpha, Interleukin-1 receptor type I, p80, CD121a
IL-1R-alpha, Interleukin-1 receptor type I, p80, CD121a
Uniprot:
Host:
Armenian Hamster
Species Reactivity:
Mouse
Specificity:
Anti-IL-1R In Vivo Antibody – Low Endotoxin (JAMA-147) recognizes Mouse IL-1 R1
Purification Method:
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background:
IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1alpha and IL-1beta exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1alpha and IL-1beta, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.
Immunogen:
Extracellular domain of mouse IL-1 R type 1
Concentration:
1.0 – 5.0 mg/ml
Formulation:
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
Purity:
>95% by SDS-PAGE and HPLC
>98% by SDS-PAGE and HPLC
Endotoxin:
≤ 1.0 EU/mg as determined by the LAL method
≤ 0.75 EU/mg as determined by the LAL method
Aggregation:
Aggregation level ≤ 5%
Aggregation level ≤ 1%
Storage:
anti-IL-1R In Vivo Antibody – Low Endotoxin (JAMA-147) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles
Applications:
Immunoprecipitation, Western Blot, Blocking, Flow Cytometry
Application Notes:
Each investigator should determine their own optimal working dilution for specific applications.
Use:
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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