Anti-Mouse CD126 In Vivo Antibody – Low Endotoxin (15A7) [ICH1104]
$184.00 – $313.00
Bulk anti-CD126 In Vivo Antibody – Low Endotoxin (15A7)
Product Benefits:
ichorbio’s anti-CD126 In Vivo Antibody – Low Endotoxin (15A7) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio’s low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio’s low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin (<0.75EU/mg) at an even higher purity (98% versus 95%). ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
Target:
CD126
Clone:
15A7
Isotype:
Rat IgG2b
Other Names:
Interleukin-6 receptor subunit alpha, Il6ra, IL-6R-alpha, IL-6RA
Uniprot:
Host:
Rat
Species Reactivity:
Mouse
Specificity:
Anti-CD126 In Vivo Antibody – Low Endotoxin (15A7) recognizes an epitope on Mouse CD126. The D7715A7 (Clone 15A7) antibody blocks IL-6/IL-6 receptor interactions
Purification Method:
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution:
Activated T and B cells, monocytes, hepatocytes, plasma cells
Background:
CD126 is an 80 kD IL-6 receptor alpha chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor beta chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The beta chain does not bind IL-6 by itself, but associates with the alpha-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation.
Immunogen:
OKT4 hybridoma cells
Concentration:
1.0 – 5.0 mg/ml
Formulation:
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
Purity:
>95% by SDS-PAGE and HPLC
>98% by SDS-PAGE and HPLC
Endotoxin:
≤ 1.0 EU/mg as determined by the LAL method
≤ 0.75 EU/mg as determined by the LAL method
Aggregation:
Aggregation level ≤ 5%
Aggregation level ≤ 1%
Storage:
anti-CD126 In Vivo Antibody – Low Endotoxin (15A7) is stable when stored at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:
Western Blot, Functional Assays
Application Notes:
Each investigator should determine their own optimal working dilution for specific applications.
Use:
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control:
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