Bulk Ado-trastuzumab emtansine – Research Grade
ichorbio’s Ado-trastuzumab emtansine Biosimilar – Research Grade is manufactured in a cGMP compliant facility. ichorbio: the best antibodies for in vivo research.
ichorbio’s research grade ado-trastuzumab emantsine biosimilar is available in the following sizes:
ichorbio regularly manufactures bulk multi-gram amounts of our ado-trastuzumab emantsine biosimilar – please contact us for pricing.
Receptor tyrosine-protein kinase erbB-2, MLN 19, HER2, HER2/neu
Detects human HER2. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Ado-trastuzumab emtansine.
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Ado-trastuzumab emtansine is a HER2-targeted antibody-drug conjugate which contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug DM1 via the stable thioether linker MCC. Trastuzumab is produced by Chinese hamster ovary cells, and DM1-MCC are produced by chemical synthesis. Ado-trastuzumab emtansine contains an average of 3.5 DM1 molecules per antibody.
1.0 – 5.0 mg/ml
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
>95% by SDS-PAGE and HPLC
≤ 0.75 EU/mg as determined by the LAL method
Ado-trastuzumab emtansine Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Each investigator should determine their own optimal working dilution for specific applications.
ichorbio’s ado-trastuzumab biosimilar emtansine is for research use only: it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.