Denosumab Biosimilar - Research Grade

Pape J et al. RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone model osteoclast activation in a human in vitro ameloblastoma-bone model. J Tissue Engineering, 2022, 13:1-10.

Narsimhan et al. Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies. Analytical Chemistry, 2023, 95, 44: 16116-16122.

Human

RANKL

1.0 - 5.0 mg/ml

Human IgG2

Humanized

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Detects human RANK Ligand. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Denosumab.

Blue ice

Receptor activator of nuclear factor-kappa B ligand (RANKL) is a master regulator of osteoclast differentiation and a key target in bone-biology research. This research-grade anti-human RANKL recombinant monoclonal antibody is an unconjugated, non-therapeutic analog of denosumab, built around the RANKL target as a human IgG2 for research use only. Manufactured to in vivo standards as an ultra-pure, low-endotoxin preparation, it is supplied in scalable milligram to gram quantities for high-throughput and bulk laboratories. The antibody supports preclinical applications including RANKL-blocking assays, in vitro osteoclastogenesis studies, and in vivo models of bone remodelling.

Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254, Rank Ligang

O14788

ICH3001-100ml ICH3002-100ml ICH3003-100ml

https://www.imgt.org/mAb-DB/