Anti-Mouse TCR Gamma/Delta (UC7-13D5) In Vivo Antibody - Low Endotoxin

Mouse

TCR gamma/delta

>1mg/ml

Armenian Hamster IgG

Armenian Hamster

Aggregation level ≤ 5%

Unknown

gamma/delta TCR expression is observed on a subset of cells in the thymus, intestinal epithelium, skin, liver, peripheral lymphoid tissues, and peritoneum. The gamma/delta TCR is involved in the antigen recognition of some bacterial or tumor-associated an

ICH3001-100ml ICH3002-100ml ICH3003-100ml

Blue ice

This is the UC7-13D5 clone, an Armenian Hamster IgG monoclonal raised against the constant region of the mouse T cell receptor gamma/delta (gammadelta TCR). It reacts with mouse and is validated for flow cytometry, immunoprecipitation, and in vivo depletion, making it well suited to functional immunology studies that require identification, isolation, or in vivo removal of gammadelta T cells. Because it binds a shared constant determinant of the gammadelta TCR rather than a single Vgamma or Vdelta chain, it labels the broad gammadelta compartment across tissues. Supplied as a low-endotoxin (<1 EU/mg research grade; ultra-low <0.5 EU/mg option) preparation in bulk milligram-to-gram quantities, it is formatted for repeated in vivo dosing where endotoxin load and aggregate content matter for reproducibility and animal welfare. The Armenian Hamster IgG format is a common depleting/blocking scaffold in mouse work. This is a research-use-only reagent; all content here is guidance for ichorbio to review before publishing. Gammadelta T cells are an innate-like lymphocyte lineage whose antigen receptor pairs a gamma and a delta chain instead of the alpha/beta chains found on conventional T cells. They typically develop early in the thymus, are enriched at epithelial and mucosal barriers (skin, gut, lung, reproductive tract) and in secondary lymphoid tissue, and recognize ligands including stress-induced molecules, phosphoantigens, and lipids, often without classical MHC restriction. Functionally they bridge innate and adaptive immunity: they respond rapidly, produce IFN-gamma or IL-17, exert cytotoxicity, and shape antimicrobial defense, tissue repair, and tumor immunosurveillance. Distinct subsets are defined largely by their Vgamma chain usage and effector program. In mouse tumor and infection models, gammadelta T cells can be protective or, via IL-17, pro-tumorigenic, which makes selective in vivo depletion or tracking of the compartment a valuable experimental tool.

TCR gamma chain, TCR delta chain, UC7 13D5, UC713D5

UC7-13D5

The anti-mouse γ/δ T-cell receptor antibody reacts with all mouse TCR γ/δ heterodimers.

This monoclonal antibody was purified using Protein A

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.

anti-TCR gamma/delta In Vivo Antibody - Low Endotoxin (UC7-13D5) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Av

Flow Cytometry, Immunoprecipitation, In vivo Depletion

In vivo Depletion: This Clone UC7-13D5 has been used for the depletion of TCR gamma/delta T cells in vivo Each investigator should determine their own optimal working dilution for specific applications.

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

BE0070

Anti-Mouse TCR Gamma/Delta (UC7-13D5) In Vivo Antibody - Low Endotoxin

Q: Is clone UC7-13D5 suitable for in vivo depletion?

A: Yes, UC7-13D5 is supplied in a low-endotoxin, in vivo-grade format suitable for in vivo gamma delta T-cell depletion as well as in vitro work.

Q: Can I order clone UC7-13D5 in bulk?

A: Yes, it is produced in scalable milligram to gram quantities for bulk and high-throughput in vivo experiments.

Q: What does clone UC7-13D5 target?

A: UC7-13D5 is an anti-mouse TCR gamma/delta monoclonal antibody used to identify and deplete gamma delta T cells; for research use only.