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Bulk Anti-Human CD11a (38) Antibody
$400.00 - $2,945.00
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Bulk Anti-Human CD11a (38) Antibody
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE and HPLC
Species Reactivity
Human
Target
CD11a
Concentration
1.0 - 5.0 mg/ml
Isotype
Mouse IgG2a
Host
Mouse
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Application Notes
Each investigator should determine their own optimal working dilution for specific applications.
Applications
Flow Cytometry, Western Blot, IHC (Frozen), Immunofluorescence, Immunoprecipitation
Storage
anti-CD11a In Vivo Antibody - Low Endotoxin (38) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Purification Method
This monoclonal antibody was purified using Protein A
Specificity
Anti-CD11a In Vivo Antibody - Low Endotoxin (38) recognizes Human CD11a. Anti-Human CD11a (Anti-LFA-1a) recognizes the (Mr 175 kDa) a chain of the leukocyte function associated antigen-1 (LFA-1). The leukocyte integrin LFA-1 is a member of a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions. LFA-1A binds to domain 1 of an intercellular adhesion molecule (ICAM) on target tissues.
Shipping Conditions
Blue ice
Background
CD11a is the alpha-L integrin subunit of LFA-1, a leukocyte adhesion molecule essential for cell migration, firm adhesion and immune-synapse stability. Clone 38 (38.0) is a mouse IgG2a monoclonal antibody against human CD11a, validated for flow cytometry, Western blot, frozen-section IHC, immunofluorescence and immunoprecipitation. Low endotoxin clone 38 is manufactured to in vivo standards and produced in scalable milligram (mg) to gram (g) quantities for high-throughput and heavy-usage research programs. As a non-therapeutic, research-use-only (RUO) reagent, it delivers reproducible results for integrin and leukocyte adhesion studies.
Other Names
LFA-1 alpha, LFA-1A, Integrin alpha-L, ITGAL
Clone
38
Uniprot
P20701
Buffer
ICH3001-100ml
ICH3002-100ml
ICH3003-100ml
Antigen Distribution
The CD11a antigen is present on most leukocytes and plays a vital role in cellular immune responses which require adhesion. Lymphocyte activation via the T-cell antigen receptor (TCR) up-regulates LFA-1 function. The absence of LFA-1A or B may induce the
Immunogen
Unknown
Aggregation
Aggregation level ≤ 5%
Antibodies Against The Same Target
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