Alemtuzumab Biosimilar - Research Grade

Gravina, A. et al. Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression. Nat Biotechnol, 2023, 41, 717–727.

Gravina et al. Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity. Cell Stem Cell, 2023, 30, 1538–1548

Iadonato et al. A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors. Front Immunol, 2023; 14: 1311658.

Human

CD52

1.0 - 5.0 mg/ml

Human IgG1 Kappa

Humanized

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Detects human CD52. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Alemtuzumab.

Blue ice

CD52 is a small glycosylphosphatidylinositol-anchored glycoprotein expressed at high density on lymphocytes, making it a focal point in immune-cell depletion research. This research-grade anti-human CD52 recombinant monoclonal antibody is an unconjugated, non-therapeutic analog of alemtuzumab designed for research use only. Produced to in vivo standards as an ultra-pure, low-endotoxin human IgG1-kappa, it is supplied in scalable milligram to gram quantities to support high-throughput and bulk laboratories. The antibody functions as a dependable isotype-matched control and active reagent for preclinical applications spanning in vitro screening, lymphocyte-depletion studies, in vivo models, ADCC assays, and antibody-drug conjugate development.

Campath-1 antigen, Cambridge pathology 1 antigen, HE5

P31358

ICH3001-100ml ICH3002-100ml ICH3003-100ml

https://www.imgt.org/mAb-DB/