ichorbio supplies a range of HLA-DR antibodies including low endotoxin versions for in vivo research and conjugated antibodies for flow cytometry, western blotting and related applications.
HLA-DR antibodies: Low Endotoxin
HLA-DR antibodies: Conjugated
ichorbio supplies a range of conjugated antibodies to HLA-DR.
HLA-DR is an isotype of MHC class II together with HLA-DP, HLA-DM, HLA-DO and HLA-DQ
HLA-DR is encoded on chromosome 6 in the region 6p21; the DR isotype is located specifically at 6p21.31. HLA-DR is made up of two subunits: alpha (α) and beta (β).
|Subunit name||Gene||Chromosomal locus|
MHC Class II
MHC Class II proteins are up-regulated in response to signalling as part of the immune response. They form a complex with foreign peptides generally 9 to 30 amino acids in length on the outside of cells which together act as a ligand for the T-cell receptor (TCR) which causes the multiplication of T-helper cells (also called CD4 positive T cells). These cells in turn stimulate antibody-producing B-cells to produce antibodies to the specific foreign peptide that was presented.
Please see image 1 below for a schematic:
HLA-DR in Disease
Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival). Good matching of these antigens between host and donor is most critical for achieving graft survival.
HLA-DR is also involved in several autoimmune conditions, disease susceptibility and disease resistance. It is also closely linked to HLA-DQ and this linkage often makes it difficult to resolve the more causative factor in disease.
HLA DR alleles that are associated with autoimmune diseases:
|HLA Allele||Disease||Relative Risk|
|HLA-DR2||Systemic lupus erythematosus||2-3|
|Primary Sjögren syndrome||10|
|Diabetes mellitus type 1||5|
|Systemic lupus erythematosus||2-3|
|Diabetes mellitus type 1||6|
|HLA-DR3 and -DR4 combined||Diabetes mellitus type 1||15|